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SKYN condoms and lubricants do not contain Nonoxynol-9. Though the use of Nonoxynol-9 was previously widespread across the world, products containing N9 – as it is also known – have never been manufactured or sold under the SKYN brand. The World Health Organisation has stated that "there is no evidence that condoms lubricated with N9 are more effective in preventing pregnancy than lubricated condoms without N9". Furthermore, the compound can cause irritation and retard the healing of wounds with which it has been in contact.

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